Imgt database web resources tools

Advances in antibody engineering for rheumatic diseases. Shepard H. Developments in therapy with monoclonal antibodies and related proteins. Wilkinson M. Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Sign In or Create an Account. Sign In. Advanced Search.

Search Menu. Article Navigation. Close mobile search navigation Article Navigation. Volume Article Contents Abstract. AXIS I Understanding the adaptive immune response: gene characterization and knowledge of their genomic organization.

Taciana Manso , Taciana Manso. Oxford Academic. Joumana Jabado-Michaloud. Anjana Kushwaha. Viviane Nguefack Ngoune. Maria Georga. Ariadni Papadaki. Chahrazed Debbagh. Morgane Bertignac , Morgane Bertignac. Saida Hadi-Saljoqi. Karima Cherouali. Safa Aouinti. Amar El Hamwi. Alexandre Albani. Merouane Elazami Elhassani. Benjamin Viart. Agathe Goret. Anna Tran. Gaoussou Sanou. Patrice Duroux. Sofia Kossida. To whom correspondence should be addressed. Revision received:.

Select Format Select format. Permissions Icon Permissions. Open in new tab Download slide. Table 1. New IMGT concepts and their definitions. New IMGT concepts. Open in new tab. Table 2.

NCBI Assembly. Chromosomal localization. IMGT locus Accession numbers. Table 3. Table 4. IMGT tools. Identification of the closest germline V, D and J genes and alleles 3. Identification of indels and their corrections optional 17 6. Advanced functionality for Clinical application: search for CLL subsets 2 and 8 optional 34 , Google Scholar Crossref.

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Fruit Development. Combinatorial pharmacogenomic algorithm is predictive of sertraline metabolism in patients with major depressive disorder. Citing articles via Google Scholar. Determinants of the temperature adaptation of mRNA degradation. Comprehensive analysis of prime editing outcomes in human embryonic stem cells. IMGT provides biologists with an easy to use and friendly interface. Two thirds of the visitors are equally distributed between the European Union and the United States.

The information provided by IMGT is of much value to clinicians and biological scientists in general. Google Scholar. Nucleic Acids Res , Immunogenetics DOI Immunogenetics , Tissue Antigens , Bioinformatics , Article Google Scholar.

Lefranc, M-P Nomenclature of the human immunoglobulin genes. Lefranc, M-P Locus maps and genomic repertoire of the human Ig genes. Immunologist , CAS Google Scholar. Lefranc, M-P Locus maps and genomic repertoire of the human T-cell receptor genes. Exp Clin Immunogenet , A new section of experimental and clinical immunogenetics. Lefranc, M-P Unique database numbering system for immunogenetic analysis. Immunol Today , J Mol Biol , Lefranc, M-P Web sites of Interest to immunologists.

In: Cesnik B et al eds. Dev Comp Immunol , in press. Leukemia , Download references. I am deeply grateful to the IMGT team for its expertise and constant motivation. You can also search for this author in PubMed Google Scholar. Reprints and Permissions. Lefranc, MP. Leukemia 17, — Download citation. Received : 24 April Accepted : 06 May Published : 03 January Issue Date : 01 January Anyone you share the following link with will be able to read this content:.

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Download PDF. Introduction The molecular synthesis and genetics of the immunoglobulin IG and T cell receptor TR chains is particularly complex and unique as it includes biological mechanisms such as DNA molecular rearrangements in multiple loci three for IG and four for TR in humans located on different chromosomes four in humans , nucleotide deletions and insertions at the rearrangement junctions or N-diversity , and somatic hypermutations in the IG loci for review Refs 1, 2.

Figure 1. Full size image. Concept of identification: standardized keywords: IMGT standardized keywords for IG and TR include the following: 1 General keywords : indispensable for the sequence assignments, they are described in an exhaustive and non-redundant list, and are organized in a tree structure. Concept of description: standardized sequence annotation: On hundred and seventy-seven feature labels are necessary to describe all structural and functional subregions that compose IG and TR sequences, 7 whereas only seven of them are available in EMBL, GenBank or DDBJ.

IMGT Bloc-notes The IMGT Bloc-notes provides numerous hyperlinks towards the Web servers specializing in immunology, genetics, molecular biology and bioinformatics associations, collections, companies, databases, immunology themes, journals, molecular biology servers, resources, societies, tools, etc.

Figure 2. Figure 3. Conclusion The information provided by IMGT is of much value to clinicians and biological scientists in general.